- Richard E. Byrd starts an expedition to Antarctic; returns in 1930.
- The first television is sold -- a Daven for $75.
- Mickey Mouse appears in Steamboat Willie, the third Mickey Mouse cartoon released, but the first sound film.
- The Academy Awards are handed out for the first time.
- Alexander Fleming discovers penicillin.
- An iron lung respirator is used for the first time at Children's Hospital, Boston.
Historical Highlights from 1928